PIEF&SLEEP: The influence of melatonin and CBD on your circadian system

Our sleep rhythm is strongly controlled by internal biological processes – the so-called circadian system. PIEF&SLEEP targets precisely this system, combining the effects of melatonin and cannabidiol (CBD) for profound sleep optimization. As one of Canasups' most advanced products, it clearly stands out from traditional sleep aids.
Understanding the internal clock
The circadian rhythm is a biological clock that controls all bodily functions in a 24-hour cycle. Light, darkness, and hormonal processes such as the release of cortisol and melatonin influence when we become tired and how deeply we sleep. Without a functioning "body clock," even 8 hours of sleep can be tiring.
This is where PIEF&SLEEP comes into play – it influences the body's own melatonin production via neurochemical signaling pathways and combines this with the anti-anxiety effect of CBD.
Melatonin – more than a sleep hormone
Melatonin is produced in the pineal gland as soon as it gets dark. It induces the body to relax, lowers body temperature, and slightly reduces blood pressure—an effect that is often underestimated. Interestingly, melatonin also has antioxidant and immunomodulatory effects.
PIEF&SLEEP contains 0.7 mg, the maximum daily dose permitted in Germany—an effective dose without suppressing your body's natural production in the long term. Important: Melatonin only develops its full effect in dark environments, so please avoid a Netflix binge night under neon lights ;)
CBD in the circadian context
Cannabidiol influences receptors such as CB1, CB2, and 5-HT1A—all of which are involved in the regulation of sleep. It has calming, anxiolytic, and anti-inflammatory effects—properties that can be particularly crucial for those with difficulty falling asleep or restless deep sleep.
In addition, studies show that CBD strengthens plasticity in the hippocampus, which improves emotional balance – a real game changer, especially for people with elevated stress levels.
What makes PIEF&SLEEP special
PIEF&SLEEP is Germany's first smart supplement combination of CBD and melatonin specifically for cannabis users. The spray is easy to use (two sprays on the tongue), works within 15–30 minutes, and is particularly suitable for:
- People with jet lag or irregular shift work
- Athletes who want to optimize their deep sleep phases
- Cannabis users who want to stabilize their internal clock
Unlike synthetic sleeping pills, it is not addictive and has hardly any side effects – unless you overdose, in which case it can lead to sluggish mornings 😉
By the way: It can also be useful in combination with NATURE+ for THC detoxification or MANGO+ for high enhancement – depending on the desired effect.
How to integrate it sensibly into your sleep routine
Here is a suggestion for your “CBD+Melatonin Sleep Routine”:
- 1 hour before bedtime: no more screen light (blue light filter glasses optional)
- 30 minutes before bedtime: 2 sprays of PIEF&SLEEP under the tongue
- Directly after: Relaxing music, no more dopamine from TikTok, Insta & Co.
- After 10 days of use: Take a 2-day break to maintain melatonin sensitivity
Additionally, you can search Germany's leading provider of hemp supplements for suitable combination products – such as Omega+ for brain & heart or Nature+ for liver support.
Comparison with other Canasups formulas
PIEF&SLEEP is focused on sleep rhythm & relaxation – unlike:
- MANGO+: Activating, uplifting, ideal in the morning
- NATURE+: Supports THC degradation and liver function
- OMEGA+: For mental clarity and anti-inflammatory
For holistic sleep quality, we recommend combining PIEF&SLEEP in the evening with Nature+ in the morning. This way, you can get the most out of your circadian system.
Canasups stands for intelligent, legal, effective, and vegan products – specifically for people who consume cannabis or want to integrate it into their daily lives. And not just for good dreams, but for holistic well-being.